Art of a Scientist is an annual offering from Duke Department of Science and Communication. The curators pair up artists and scientists in experimental collaborations to make science and data accessible to a wider audience. The 2021 exhibit was an online zine produced by The Power Company Gallery and ran through the month of March 2021. Some people had trouble accessing the piece via the Zine so Latent to Lytic is posted below.
This year brings another opportunity to stretch my understanding of scientific data and ideas by sounding them out! I worked with graduate student Elizabeth Goins from NCCU on her study of the effects of exogenous ethanol and acetate on Kaposis-Sarcoma -associated Human Herpes Virus (KSHV). In addition, visual artist Heather Sanchez rendered the process through illustrations/animation!
KSHV enters the cell via glycoproteins on the surface of the host cell. The virus is carried through the cell by a special protein, and ends up in the nucleus. The virus remains latent in the nucleus until triggered into the lytic or active infection phase. Once triggered into lytic, there is a gene “cascade” that functions as a sort of assembly line of viral replication and is cytopathic to the cell. Goins found that both ethanol and acetate accelerate replication of the virus in human cells. Acetate, which is a biproduct of ethanol in the human body, not only accelerates viral replication but can actually trigger the change from latent to lytic.
The sonic illustration begins with the song phrase of a healthy cell replete with an active lipid bilayer! A rustling, rattling sound is the virus entering via the glycoproteins. Then a new voice enters and attaches to the song phrase of the healthy cell- this is the voice of the virus. The virus adds a new melodic aspect to the healthy cell song phrase, then works into and alters the nucleas, represented by percussion. Acetate burbles into the soundscape and triggers the lytic phase. The virus is now reactivated in its own song phrase with multiple replications resounding. Sanchez’s illustrations depict infected latent cells, the virus itself, with a 40 second animation of the entire process at the end of the sonic illustration.